b'Reference | MenusNext-GenerationSequencing MenuInvivoscribe offers LymphoTrack and LymphoTrack Dx Assays forand the multiplexing capability to generate a sequencing library that the analysis of B- and T-cell clonality, somatic hypermutation, andcombines amplicons from different Invivoscribe LymphoTrack minimal residual disease studies**. Assays are designed for use onandLymphoTrack Dx Assays onto the same sequencingboth industry standard next-generation sequencing (NGS) platforms:chip, reducing per sample testing costs.the Illumina MiSeq and Thermo Fisher Scientific Ion PGM and Ion S5 instruments. All LymphoTrack and LymphoTrack Dx Assays allow for fast and easy analysis and data visualization using the included bioinformatics Invivoscribe assays for the Illumina MiSeq platform offer the abilitysoftware. The LymphoTrack software sorts and assigns the sequences to analyze up to twenty two samples and two controls per gene targetto their corresponding sample and provides information such as the and the multiplexing capabilities to generate a sequencing libraryprevalence, gene segment usage, and the mutation rate (IGH Leader that combines amplicons from different Invivoscribe LymphoTrack andand IGH FR1 only). In addition, the Invivoscribe Minimal Residual LymphoTrack Dx Assays onto the same flow cell. Our included softwareDisease (MRD) Software allows for clonotype sequences to be tracked then sorts and assigns the correct sequences to their correspondingin subsequent samples for research applications.sample. The table below indicates which LymphoTrack (Research Use Only) Invivoscribe assays for the Ion PGM and Ion S5 platform offer theand LymphoTrack Dx (CE-IVD Marked) Assays are currently available ability to analyze up to ten samples and two controls per gene targetin 2020.CE-Marked IVD AssaysMiSeqIon S5/PGM LymphoTrack Dx IGHV Leader Somatic Hypermutation Assays AVAILABLE NOT AVAILABLELymphoTrack Dx IGH FR1 Assays AVAILABLE AVAILABLELymphoTrack Dx IGH FR2 Assays AVAILABLE AVAILABLELymphoTrack Dx IGH FR3 Assays AVAILABLE AVAILABLELymphoTrack Dx IGH FR1/2/3 Assays AVAILABLE AVAILABLELymphoTrack Dx IGK Assays AVAILABLE AVAILABLELymphoTrack Dx TRG Assays AVAILABLE AVAILABLELymphoTrack Dx TRB Assays AVAILABLE PLEASE INQUIREResearch Use Only (RUO) Assays MiSeqIon S5/PGM LymphoTrack IGHV Somatic Hypermutation Assays AVAILABLE PLEASE INQUIRELymphoTrack IGH FR1 Assays AVAILABLE AVAILABLELymphoTrack IGH FR2 Assays AVAILABLE AVAILABLELymphoTrack IGH FR3 Assays AVAILABLE AVAILABLELymphoTrack IGH FR1/2/3 Assays AVAILABLE AVAILABLELymphoTrack IGK Assays AVAILABLE AVAILABLELymphoTrack TRG Assays AVAILABLE AVAILABLELymphoTrack TRB Assay AVAILABLE PLEASE INQUIRECE-marked assays are in vitro diagnostic products and are not available for sale or use within North America.**Minimal residual disease (MRD) applications are currently for research use only.156'