b'MolecularDiagnosticsTestsTest Name Indications for TestingNPM1 mutation analysis (qualitative)At initial diagnosis of AML Stratification high and low risk AML Assay Type Recurrence of leukemia after induction therapy onCapillary Electrophoresis patients not initially screened for NPM1 mutations Method DescriptionPrimers targeting exon 12 on the NPM1 gene are used to amplify the patients DNA. The size of the NPM1 PCR product is determined by capillary electrophoresis.LabPMM offers the only internationally harmonized assay for NPM1 mutations and testing is performed pursuant to patents licensed from TrovaGene, Inc. of San Diego, CA.Interpretation TurnaroundSpecimenShippingSpecimen Time Requirements Conditions StabilityAn interpretive1-3 business days1-3 mL peripheralAmbient or Cool; Room Temp report will be issuedblood in EDTA, do not freezeup to 72 hoursindicating whether aACD or Heparin (peripheral blood or2-8 C upNPM1 mutation wasbone marrow) 0.25-1 mL boneto 7 daysdetectedmarrow in EDTA,Ambient or frozen on ACD or Heparin dry ice (isolated DNA)250 ng ofpreviously isolated DNALabPMM Services Catalog 2021|21'