b'ClonalityTestsTest Name sequencing of the PCR products is used to identifyIGK Clonality AssayDNA sequences specific to clonal gene rearrangements. Bioinformatics tools facilitate the characterization of sequences present at greater than 5% of the population. Assay Type These sequences can be used to track specific clonal populations.Next-Generation Sequencing (NGS)This test is performed by using the LymphoTrack orIndications for TestingLymphoTrack Dx Assay from Invivoscribe. Identify clonality in atypical lymphoproliferativedisordersMethod Description Support a differential diagnosis between reactiveFor detection of the vast majority of IGK genelesions and hematologic malignanciesrearrangements, a multiplex master mix targeting theAssign presumptive lineage in mature monoclonalconserved V, J, C ,and kappa deleting element (K de )lymphoproliferative disordersregions is used for PCR amplification. Next-generationMonitor and evaluate disease recurrenceInterpretation TurnaroundSpecimenShippingSpecimen Time Requirements Conditions StabilityAn interpretive report will be5 to 10 1-3 mL of peripheralAmbient or2-8 C up issued indicating whetherbusiness daysblood in Heparin,Cool; do notto 7 days prior evidence of clonality wasEDTA or ACD freeze (peripheralto testingdetected. The report furtherblood or bone provides a summary of the0.25-1 mL of bonemarrow) top 5 merged sequences,marrow in Heparin, including the % total reads, theEDTA or ACD Ambient or 500 ng of previouslyfrozen on dry ice rearrangement class and the sequence. isolated DNA(isolated DNA)LabPMM Services Catalog 2021|29'