b'IGK Clonality Assay Clinical InformationDuring development of lymphoid cells, antigen receptorIGK molecules are assembled from multiple polymorphic genes undergo somatic gene rearrangements. 1 gene segments that undergo rearrangements generating gene receptors unique in both length and sequence.The human immunoglobulin kappa (IGK) locus onSince leukemias and lymphomas originate from the chromosome 2 (2p11.2) includes 7 variable (V) region genemalignant transformation of individual lymphoid cells, segments and 5 joining (J) gene segments upstream ofwhich means that all leukemias and lymphomas generally the constante (C) region. The kappa deleting element (K de ),share one or more cell-specific or clonal antigen receptor approximately 24 kb downstream of the J-C region, cangene rearrangements. Therefore, tests that detect IGK also rearrange with V gene segments and the isolatedclonal rearrangements can be useful in the study of B-recombination signal sequence in the J-C intronic region. 2and T-cell malignancies.Specifically during B-cell development, genes encodingReferences1. Tonegawa S (1983) Somatic Generation of Antibody Diversity. Nature 302:575-581.2.JE Miller et al., Molecular Genetic Pathology (2013, 2nd ed.) Springer Science & Business Media 302.2.7.13 and 30.2.7.18.28'