Invivoscribe 2019 | 51 NGS RUO Assays 50 Low Positive Controls LymphoTrack® B-cell Low Positive Control LymphoTrack® B-cell Low Positive Control can be used as a control for: Gene Rearrangements: IGH, IGK Chromosome Translocations: n/c Mutations: n/c Catalog # Description 4-088-0098 LymphoTrack® B-cell Low Positive Control LymphoTrack® T-cell Low Positive Control LymphoTrack® T-cell Low Positive Control can be used as a control for: Gene Rearrangements: TRB, TRG Chromosome Translocations: n/c Mutations: n/c Catalog # Description 4-088-0108 LymphoTrack® T-cell Low Positive Control Minimal Residual Disease (MRD) testing is a valuable tool that allows investigators to study and monitor multiple myeloma (MM) , chronic lymphocytic leukemia (CLL), acute lymphoblastic leukemia (ALL), acute myelogenous leukemia (AML) and other hematologic diseases. Recent treatment advances have led to significantly increased clinical response and overall survival, but ultimately most subjects will relapse, driving the need for sensitive MRD monitoring. Sensitive and standardized testing such as NGS-based MRD may one day enable identification of those cases that will eventually relapse versus those who are potentially cured1 . In addition to the need for more sensitive tracking, it is clear that standardized methods are needed. Currently, MRD methods are highly subjective and recommendations are often based on consensus expert-shared knowledge and experience, not on a validated, objective method. Once specific rearrangements have been identified, LymphoTrack assays can be used with LymphoQuant and LymphoTrack Low Positive Controls to track these clonotype populations to a sensitivity as low as 10-6 . Internal Controls LymphoQuant® B-cell Internal Control LymphoQuant B-cell Internal Control can be used as a low level control for: Gene Rearrangements: IGH, IGK Chromosome Translocations: n/c Mutations: n/c Catalog # Description 4-088-0118 LymphoQuant® B-cell Internal Control LymphoQuant® T-cell Internal Control LymphoQuant T-cell Internal Control can be used as a low level control for: Gene Rearrangements: TRB, TRG Chromosome Translocations: n/c Mutations: n/c Catalog # Description 4-088-0128 LymphoQuant® T-cell Internal Control LymphoQuant T-cell or B-cell Internal Controls may be spiked into specimens to estimate the respective number of clonotype T-cell or B-cell equivalents present. Addition of the LymphoQuant Internal Control to the specimen PCR facilitates clonotype tracking over time without any additional sequencing cost. Consistent use of a LymphoQuant Internal Control enables investigators to objectively monitor the disease over time with a highly standardized, sensitive method. The LymphoTrack MRD software will help researchers that use the LymphoQuant Internal Control, calculate and report an estimated number of clonotype cell equivalents and the percent clonotype in the sample, enabling researchers and pharmaceutical companies to accurately monitor hematologic disease in longitudinal studies. Note: Same product listed on page 132 in DNA controls Note: Same product listed on page 133 in DNA controls MRD RUO Assays Minimal Residual Disease (MRD) Solution | Research Use Only (RUO)