10 Introduction Letter to Our Colleagues 2 Executive Leadership Team 3 Industry Pioneers 4 Over 20 Years of Experience 6 A Full Range of Collaborators 8 Background Introduction 12 Test Algorithm for Suspect Lymphoproliferations 13 Next-Generation Sequencing (NGS) LymphoTrack® Dx Assays 14 LymphoTrackDx IGHV Leader Somatic Hypermutation Assay 16 LymphoTrackDx IGH FR1/2/3 Assays 18 LymphoTrackDx IGK Assays 22 LymphoTrackDx TRG Assays 24 LymphoTrackDx TRB Assays 26 LymphoTrackDx Bioinformatics Software 28 LymphoTrack® Assays Research Use Only (RUO) 30 LymphoTrack IGHV Leader Somatic Hypermutation Assay 32 LymphoTrack IGH FR1/FR2/FR3 Assays 34 LymphoTrackIGK Assays 38 LymphoTrackTRG Assays 40 LymphoTrackTRB Assays 42 LymphoTrackBioinformatics Software 43 LymphoTrackMRD Bioinformatics Software 44 LymphoTrack® MRDSolution 45 LymphoTrack Minimal Residual Disease (MRD) Software 48 LymphoTrack B-cell & T-cell Low Positive Controls 50 LymphoQuant B-cell & T-cell Internal Control 51 Gel and Capillary IdentiCloneTM Assays 52 IGH + IGK B-Cell Clonality Assays 54 IGH Gene Clonality Assays 56 IGK Gene Clonality Assays 58 IGL Gene Clonality Assays 60 TCRB + TCRG T-Cell Clonality Assays 62 TCRB Gene Clonality Assays 64 T-Cell Receptor Gamma Gene Rearrangement Assay 2.0 66 TCRG Gene Clonality Assays 68 TCRD Gene Clonality Assays 70 BCL1/JH Translocation Assay 72 BCL2/JH Translocation Assay 74 LeukoStrat® Assays 76 FLT3 Mutation Assay - Gel Detection 78 FLT3 Mutation Assay 2.0 - ABI Fluorescence Detection 80 CDx FLT3 Mutation Assay 82 CDx FLT3 Mutation Assay - Japan 84 Gel and Capillary - Research Use Only (RUO) Assays 86 IGH + IGK B-Cell Clonality Assays 88 IGH Gene Rearrangement Assays 90 IGH Gene Clonality Assays 92 IGK Gene Clonality Assays 94 IGL Gene Clonality Assays 96 TCRB + TCRG T-Cell Clonality Assays 98 TCRB Gene Clonality Assays 100 T-Cell Receptor Gamma Gene Rearrangement Assay 2.0 102 T-Cell Receptor Gamma Gene Rearrangement Assays 104 TCRG Gene Clonality Assays 106 TCRD Gene Clonality Assays 108 BCL1/JH Translocation Assay 110 BCL2/JH t(14;18) Translocation Assay 112 BCL2/JH Translocation Assay 114 BCR/ABL t(9;22) Translocation Assays 116 PML/RARa t(15;17) Translocation Assays 118 IGH Somatic Hypermutation Assays v2.0 120 FLT3 Mutation Assays 122 Analyte Specific Reagents Analyte Specific Reagents 124 Controls, Reagents, and Enzymes Overview 126 DNA Controls 128 Low Positive Controls 132 Internal Controls 133 RNA Controls 134 Control Panels 138 Master Mix Controls 140 Reagents 141 Enzymes 141 Custom Products Custom Products 142 Reference Clonality Testing Workflow Methods 145 Illumina® MiSeq® Workflow Summary 146 Thermo Fisher Scientific® Ion S5™ PGM™ Workflow Summary 147 Next-Generation Sequencing Menu 148 Gel and Capillary Electrophoresis Menu 149 Hematologic Malignancy Research and Testing Guide 150 Common Technical Support Questions 151 Recent Poster Abstracts 154 Product List Product List by Catalog Number 157 Index Alphabetical Index 160 Table of Contents Improving Lives with Precision Diagnostics