b'Minimal Residual Disease (MRD) Solution | Research Use Only (RUO)Low Positive ControlsMinimal Residual Disease (MRD) Solution Internal Controls Minimal Residual Disease (MRD) SolutionLow Positive Controls Internal ControlsMinimal Residual Disease (MRD) testing is a valuable tool that allowsLymphoQuant T-cell or B-cell Internal Controls may be spiked into specimensinvestigators to study and monitor multiple myeloma (MM) , chronic lymphocyticto estimate the respective number of clonotype T-cell or IGH equivalentsleukemia (CLL), acute lymphoblastic leukemia (ALL), acute myelogenous leukemiapresent.Addition of the LymphoQuant Internal Control to the specimen PCR (AML) and other hematologic diseases. Recent treatment advances have led tofacilitates clonotype tracking over time without any additional sequencing cost. significantly increased clinical response and overall survival, but ultimately mostConsistent use of a LymphoQuant Internal Control enables investigators to subjects will relapse, driving the need for sensitive MRD monitoring. Sensitiveobjectively monitor the disease over time with a highly standardized, sensitive and standardized testing such as NGS-based MRD may one day enablemethod. The LymphoTrack MRD software will help researchers that use the identification of those cases that will eventually relapse versus those who areLymphoQuant Internal Control, calculate and report an estimated number of potentially cured. In addition to the need for more sensitive tracking, it is clearclonotype cell equivalents and the percent clonotype in the sample, enabling that standardized methods are needed. Currently, MRD methods are highlyresearchers and pharmaceutical companies to accurately monitor hematologic subjective and recommendations are often based on consensus expert-shareddisease in longitudinal studies.knowledge and experience, not on a validated, objective method. Once specific rearrangements have been identified, LymphoTrack assays can be used with LymphoQuant and LymphoTrack Low Positive Controls to track these clonotype populations to a sensitivity as low as 10 -4 .LymphoTrack B-cell Low Positive ControlLymphoQuant B-cell Internal Control LymphoTrack B-cell Low Positive Control can be used as a control for: LymphoQuant B-cell Internal Control can be used to objectively track Ig Gene Rearrangements:IGHclonotypes.Chromosome Translocations:n/c Gene Rearrangements:IGH Mutations:n/cChromosome Translocations:n/cMutations:n/c Catalog # Description Catalog # Description4-088-0098 LymphoTrack B-cell Low Positive Control 4-088-0118 LymphoQuant B-cell Internal ControlLymphoTrack T-cell Low Positive ControlLymphoQuant T-cell Internal ControlLymphoTrack T-cell Low Positive Control can be used as a control for: LymphoQuant T-cell Internal Control can be used to objectively track TCR Gene Rearrangements:TRB, TRGclonotypes. Chromosome Translocations:n/cMutations:n/cGene Rearrangements:TRB, TRG Chromosome Translocations:n/cMutations:n/c Catalog # Description Catalog # Description4-088-0108 LymphoTrack T-cell Low Positive Control 4-088-0128 LymphoQuant T-cell Internal ControlNote: Same product listed on page 136 in DNA controls section. Note: Same product listed on page 137 in DNA controls section.MRD applications are for Research Use Only (RUO); not intended for in vitro diagnostic use.MRD applications are for Research Use Only (RUO); not intended for in vitro diagnostic use. 58Invivoscribe 2021|59'