b'Minimal Residual Disease (MRD) Solution | Research Use Only (RUO)MGRSDNMRD Software MRD Software RUO AssaysMinimal Residual Disease (MRD) Solution Minimal Residual Disease (MRD) SolutionLymphoTrack Minimal Residual DiseaseLymphoTrack MRD Sample Report(MRD) Software This report summarizes the overall call, i.e. if a clonotype was detected or not detected, the number of checked replicates, the total DNA input, total reads analyzed and the location of all output files. The values in the PDF report are also found in the generated text files. Software Use The provided software is composed of four distinct parts: The LymphoTrack MRD Bioinformatics Software package is provided1. A Project tool that can be used to plan experiments with sufficient with each LymphoTrack Assay upon request to aid in the evaluationconfidence based on read depth, replicate count, and DNA input. of treatment response in many lymphoid malignancies such as AcuteProjects can also be Saved and Loaded for use in subsequent time Lymphoblastic Leukemia and Multiple Myeloma to minimize thepoints. risk of patients relapsing. The exceptional sensitivity and precision of NGS-based MRD tracking can accelerate clinical trials and drug2. A bioinformatics data analysis application. development. This MRD software is intended to detect the presence of clonotype sequences within the output files generated using the3. A PDF Sample Report identifying the clonal sequence(s) if present, Invivoscribe LymphoTrack Assays and accompanying LymphoTracka summary of the degree of mismatches, calculations of the read bioinformatics software; it is not intended to define the significancefrequency and the degree of confidence if clonal sequence(s) are not of these findings. Once a specific rearrangement sequence (thedetected at various sensitivities.clonotype) has been identified in a primary sample, the MRD software enables streamlined tracking of clonal populations at a sensitivity of4. A PDF Summary Report that will automatically generate longitudinal 10 -4 , or even lower limits provided sufficient DNA is tested. The MRDgraphs of up to 5 clonal frequencies for a Subject and summary tables software can be used to Create, Save and Load projects to objectivelywithestimates of clonal cell equivalents and clonal frequencies for all track up to 5 clonal sequences to monitor for disease relapse and forqueried sequences if LymphoQuant Internal Controls is used.use in drug development studies.MRD Summary Graph MRD Project PlannerThe Project Planner can be used to calculate the confidence of a true negative by adding replicate counts, resequencing counts, sequencing depth, and DNA input amount. The software assumes that the same sequencing depth and DNA input is used for each replicate.NOTE: The MRD Report may slightly differ from what is shown.Ordering InformationCatalog # Products Quantity Components7-500-0008 LymphoTrack MRD Software** 1 CD complimentary with LymphoTrack kit purchaseResearch Use Only (RUO) assays are not for sale in Europe and other global markets where equivalent CE-IVD** MRD Software can be used to track sequences generated using either LymphoTrack Assays formatted for either the Illumina or Thermo Fisher NGS platforms.assays are available and registered with the appropriate regulatory agencies. MRD applications are for Research Use Only. To obtain a copy, please contact your local distributor or send an e-mail to customerservice@invivoscribe.com56Invivoscribe 2021|57'