b'Controls, Reagents, Controls, Reagents,and Enzymes and EnzymesMRD ControlsMRD Controls Low Positive Controls Internal ControlsMinimal Residual Disease (MRD) testing is a valuable tool that allowsLymphoQuant T-cell or B-cell Internal Controls may be spiked into specimensinvestigators to study and monitor multiple myeloma (MM) , chronic lymphocyticto estimate the respective number of clonotype T-cell or IGH equivalents present.leukemia (CLL), acute lymphoblastic leukemia (ALL), acute myelogenous leukemiaAddition of the LymphoQuant Internal Control to the specimen PCR facilitates (AML) and other hematologic diseases. Recent treatment advances have led toclonotype tracking over time without any additional sequencing cost. Consistent significantly increased clinical response and overall survival, but ultimately mostuse of a LymphoQuant Internal Control enables investigators to objectivelysubjects will relapse, driving the need for sensitive MRD monitoring. Sensitivemonitor the disease over time with a highly standardized, sensitive method.and standardized testing such as NGS-based MRD may one day enableThe LymphoTrack MRD software will help researchers that use the LymphoQuant identification of those cases that will eventually relapse versus those who areInternal Control, calculate and report an estimated number of clonotype cell potentially cured. In addition to the need for more sensitive tracking, it is clearequivalents and the percent clonotype in the sample, enabling researchers that standardized methods are needed. Currently, MRD methods are highlyand pharmaceutical companies to accurately monitor hematologic disease in subjective and recommendations are often based on consensus expert-sharedlongitudinal studies.knowledge and experience, not on a validated, objective method. Once specific rearrangements have been identified, LymphoTrack assays can be used with LymphoQuant and LymphoTrack Low Positive Controls to track these clonotype populations to a sensitivity as low as 10 -4 . LymphoTrack B-cell Low Positive ControlLymphoQuant B-cell Internal Control LymphoTrack B-cell Low Positive Control can be used as a control for: LymphoQuant B-cell Internal Control can be used to objectively track Ig Gene Rearrangements:IGHclonotypes.Chromosome Translocations:n/c Gene Rearrangements:IGH Mutations:n/cChromosome Translocations:n/cMutations:n/c Catalog # Description Catalog # Description4-088-0098 LymphoTrack B-cell Low Positive Control* 4-088-0118 LymphoQuant B-cell Internal Control* LymphoTrack T-cell Low Positive ControlLymphoQuant T-cell Internal ControlLymphoTrack T-cell Low Positive Control can be used as a control for: LymphoQuant T-cell Internal Control can be used to objectively track TCR Gene Rearrangements:TRB, TRGclonotypes.Chromosome Translocations:n/c Gene Rearrangements:TRB, TRG Mutations:n/cChromosome Translocations:n/cMutations:n/c Catalog # Description Catalog # Description4-088-0108 LymphoTrack T-cell Low Positive Control* 4-088-0128 LymphoQuant T-cell Internal Control*Note: Same product listed on page 58 in MRD Solution section.Note: Same product listed on page 59 in MRD Solution section. *LymphoTrack Low Positive Controls are research use only (RUO), not for diagnostic procedures. *LymphoQuant Internal Controls are research use only (RUO), not for diagnostic procedures.136Invivoscribe 2021|137'