b'Clonality TestsThe unique process of genetic rearrangements in therearrangements in Ig and/or TCR genes. Lymphoid immunoglobulin (Ig) and T-cell receptor (TCR) gene locimalignancies are characterized by the reduced during immune cell development and maturation generatespopulation diversity of these gene loci originating from a vast pool of genetically distinct cells.the proliferative transformation of an individual lymphoid cell. The associated cellular population typically shares During early lymphoid differentiation, genes encodingone or more cell-specific or clonal antigen-receptor the Ig and TCR molecules are formed by stepwisegene rearrangements. The detection of these clonal cells rearrangement of variable (V), diversity (D), and joiningprovides the basis for clonality assessment in leukemia, (J) gene segments. During this V-D-J recombinationlymphoma, and hematologic disease diagnosis. process, nucleotides are deleted and randomly inserted at the joining sites, resulting in an enormous diversity ofInvivoscribe (LabPMMs parent company) is an industry unique antigen receptors. As Ig/TCR gene rearrangementspioneer with 25 years of experience in providing clonality occur sequentially in the earliest stages of lymphoidtest solutions. Our expertise in clonality testing assures the differentiation, they are present in almost all immature highest rates of detection of clonal populations as well as and mature lymphoid cells. international standardization of results.Since lymphoma is a cancer of the lymphatic or the immune system, the vast majority of lymphomas exhibit 24 LabPMM Services Catalog 2019|25'